باثولوجى Pathology Slides : Breast pathology

Pathology Slides : Breast pathology

 

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Fibroadenoma is the most common benign tumor of the female breast. Breast carcinoma is the second cause of cancer death in females in the world. Both seem to arise on a hyperestrogenism status.

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Fibroadenoma of the breast

Fibroadenoma of the breast is a benign tumor composed of two elements : epithelium and stroma. It is nodular and encapsulated, included in breast. The epithelial proliferation appears in a single terminal ductal unit and describes duct-like spaces surrounded by a fibroblastic stroma. Depending on the proportion and the relationship between these two components, there are two main histological features : intracanalicular and pericanalicular. Often, both types are found in the same tumor. Intracanalicular fibroadenoma (photo A) : stromal proliferation predominates and compresses the ducts, which are irregular, reduced to slits. Pericanalicular fibroadenoma (photo B) : fibrous stroma proliferates around the ductal spaces, so that they remain round or oval, on cross section. The basement membrane is intact. (H&E, ob. x10)

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Invasive ductal carcinoma of the breast

Invasive (infiltrating) ductal carcinoma of the breast is a malignant epithelial tumor resulted from proliferation of ductal epithelium of breast. It is the most common type of breast cancer (70 - 80 %). Atypical tumor cells form ribbons, tubules or nests, broke the basement membrane of the duct and infiltrate the surrounding tissues (fat tissue - photo, skeletal muscle and/or skin). Tumor cells induce desmoplastic reaction in stroma (abundant fibrosis, collagen). (H&E, ob. x20)

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