Patholgy Slides : Regeneration and Repair by Connective Tissue
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After destruction, cells and tissues can be replaced by vital cells through parenchymal regeneration or by connective tissue repair.
Repair by connective tissue starts with formation of granulation tissue. It may appear in chronic peptic ulcer, surrounding necrotic areas (infarct, inflammation) or fibrin (fibrinous inflammation, thrombus). With time, the maturation of granulation tissue will replace the damaged area with a scar
Healing (repair) by connective tissue has the granulation tissue as a hallmark. It consists of new capillaries (result of proliferation of endothelial cells - angiogenesis or neovascularization) in an edematous atmosphere of fibroblasts (spindle shaped), myofibroblasts, mononuclear inflammatory cells, macrophages, neutrophils, cellular debris. (Hematoxylin-eosin, ob. x10)
Organization of a venous thrombus
Pulmonary vein completely obliterated by a thrombus with organization. The thrombus was replaced by an immature granulation tissue, rich in newly formed capillaries, fibroblasts, collagen and reduced inflammatory infiltrate. (Hematoxylin-eosin, ob. x4)